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Abbreviations ASCA anti- Saccharomyces cerevisiae antibody FGID functional gastrointestinal disorders GF germ-free IEB intestinal epithelial barrier IBD inflammatory bowel disease IBS irritable bowel syndrome IBS-C constipation-predominant irritable bowel syndrome IBS-D diarrhea-predominant irritable bowel syndrome IBS-M irritable bowel syndrome with mixed bowel habit LPS lipopolysaccharides SCFA short-chain fatty acids

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Stage-specific interventions should emerge with acute blockade of ferroptotic lipid peroxidation followed by chronic enhancement of mitochondrial biogenesis, all while respecting circadian metabolic rhythms

doi: 10.1096/fj.202002285RR 86

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