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Although studies have shown that Nrf2 and Nrf2-activating chemicals have opposing effects on the NLRP3 inflammasome that are not dependent on Nrf2-mediated gene expression, both effects are independent of the transcriptional activity of Nrf2 [129]

Blocking the HGF/c-Met signaling pathway inhibits PNI in pancreatic cancer To further validate the c-Met-mediated finding in PNI, the lentiviral vector c-Met-shRNA was used to suppress c-Met expression in pancreatic cancer cell lines

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259 Importantly, DHEA may be contraindicated in women with PCOS, who generally have elevated levels of androgens, including DHEA-S