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Clinicians have reported cases of tramadol-induced mania in patients without a prior history of bipolar disorder (61)

The most common neurological manifestation is subacute combined degeneration of the spinal cord and peripheral sensory neuropathy, while epilepsy is a rare manifestation in cases of vitamin B12 deficiency [84]

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Song KH, Fasano A, Eddington ND

In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder NiemannPick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol -epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death (Teratani et al., 2017)