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Activating these receptors triggers a signaling cascade that upregulates hormone-sensitive lipase, which breaks down stored triglycerides into free fatty acids and glycerol essentially mobilizing stored fat for use as energy

While Ozempic may sometimes be prescribed off-label for weight loss, it is only FDA-approved to treat type 2 diabetes

Special Considerations for High-Risk Groups In individuals with comorbid conditions like obesity, prediabetes, NASH, and macronutrient deficiencies, early detection of PN is particularly important

[257] The European Medicines Agency (EMA) followed suit on 28 May 2021

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