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Excitotoxicity in neurodegenerative diseases Neurodegeneration, characterized by progressive neuronal loss, drives incurable disorders like AD, PD, HD, and amyotrophic lateral sclerosis (ALS) [60, 138]

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Glutathionylation is known to play an important role in regulating the activity of NF-B and IB [52], and glutathionylation of IKK modulates the LPS-induced release of cytokines [53]

Whereas the total glutathione (GSH+GSSG) concentrations in the epithelial lining fluid of healthy adult controls were similar to other published reference values (436 M ) (46, 233), these concentrations were reduced by more than threefold in children with severe asthma (129134 M ) (88)