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While short-term research (4-8 weeks) has been extensively studied and often shows good tolerability, long-term safety data is more limited, and several theoretical concerns warrant careful consideration

Elevated Hcy carries many short term (thrombosis) and long-term problems, best addressed ASAP

S-adenosyl methionine (SAMe), the active form of the amino acid methionine, is the major metabolite in multiple metabolic pathways on which neuronal homeostasis depends

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By preserving muscle mass during weight loss, patients set themselves up for easier weight maintenance, better physical function, and improved metabolic health