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FIGURE 1 Effects of TLYY administration on oxidative stress levels in DSS-induced mice As shown in Figures 2AC, DSS induction significantly decreased serum GSH-Px and SOD activities and increased MDA content compared to the NC group

doi: 10.1016/S1474-4422(24)00086-3 8

Building on this approach, Lus group developed YF135 , a reversible covalent PROTAC in which the fluoroacrylamide moiety of MRTX849 was replaced with a cyanoacrylamide warhead 33

This genes enzyme product is expressed in high levels in the epididymides, seminal vesicles, prostate, genital skin and liver

They aid in promoting the synthesis of collagen and elastin and support skin repair