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Viral infections are sensed by innate immunity through pattern recognition receptors (PRRs), including Toll-like receptor 3 (TLR3), retinoic acid-inducible protein I and melanoma differentiation-associated gene 5

However, this stage seems to be followed by an upregulation of anti-inflammatory cytokine, IL-10, at 14 weeks post-inoculation

10.1093/sleep/26.5.507 51 ElbazA.BowerJ

Rangroo Thrane V, Thrane AS, Chang J, Alleluia V, Nagelhus EA, Nedergaard M (2012) Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy