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Bilirubin is a fat-soluble compound which has to be transported attached to albumin on a high-affinity binding site (1:1) within the circulation to the sinusoids of the liver

While heavily studied for its regulatory control over melanogenesis (pigmentation signaling), advanced research also evaluates its interactions with energy homeostasis, lipid metabolism, and central neuroprotective pathways

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Other Golgi-localized zinc transporters also contribute to disease