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Following its release, most B 12 is absorbed by the body in the small bowel (ileum) after binding to a protein known as intrinsic factor

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, et al

Experts dont know exactly why it happens, but metformin can block the absorption of vitamin B12 in the intestine, according to an article published in 2022