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Normal microglial responses in brain tissue are obligatory for phagocytic clearance of damaged neural cells and tissue debris, but persistent or vigorous microglial responses can damage the CNS (Greenhalgh et al., 2020

It has been reported that the variation in clinical effectiveness of triple combination cream and hydroquinone was more obvious in patients with darker skin tones and also in those with mixed type of melasma ( 5.1.6 Azelaic acid Azelaic acid can inhibit the mitochondrial enzyme and DNA synthesis in melanocytes, which might be cytotoxic