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Watch for these warning signs and contact your prescriber if you notice them: Worsening anxiety, irritability, or restlessness New or worsening insomnia Increased aggressiveness or emotional volatility Worsening depression or mood swings Difficulty cutting back on alcohol Side effects that interfere with daily life If you have a pattern of heavy drinking or feel that alcohol is getting harder to control, that is worth addressing directly, not just as a medication safety issue, but as a health concern in its own right

For AOD-9604, exercise caution as long-term safety data is insufficient

As for low dose naltrexone, a few studies have also found promising results

It promotes angiogenesis, which is increased blood flow

Both groups experienced improvements in physical and mood symptom scores, but group 1 had more pronounced effects