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Exposing our lips to cold air and the sun and even neglecting to drink enough water or licking them too often can cause them to become chapped, dry, and flakey

Unresolved questions and future directions Currently, despite promising prospects in preclinical models, targeting glutamine metabolism faces challenges in clinical trials due to inherent heterogeneity in glutamine metabolism within tumor cells and immune cells, as well as its complex impact on immune responses

Metabolic control in many cases requires the use of a gastrotomy tube, which facilitates the administration of calories and of feeds at night to prevent catabolism

To link these changes to functional adaptations, we selected key nutrient transporters and metabolic enzymes for single-cell validation by spectral flow cytometry, focusing on molecules involved in amino acid uptake, glycolysis and the pentose phosphate pathway 24,25