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In future perspectives, augmenting CAR-T cell efficacy, increasing resist immunosuppressive TME, overcoming antigen loss and heterogeneity, metabolic reprogramming, avoiding the CAR-T cell exhaustion and immunological synapse dysfunction, improving tumor site trafficking and infiltration, and importantly restricting the CAR, adverse events should be considered as major goals for researchers' efforts in this field

Jonas Department of Community Medicine, Manipal Academy of Higher Education, Mangalore, India Nitin Joseph, Nithin Kumar, Rohith Motappa & Rekha Thapar Department of Economics, National Open University, Benin City, Nigeria Charity Ehimwenma Joshua Department of Family Medicine and Public Health, University of Opole, Opole, Poland Jacek Jerzy Jozwiak Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia Mikk Jrisson Department of Radiology and Nuclear Medicine, University of Jordan, Amman, Jordan Malik E

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DOI: 10.1056/NEJMoa063070 Aaron SD, Vandemheen KL, Fergusson D, et al

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