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The majority of the reports originate from the United States (25,788, 46.85%) and Japan (8,794, 15.98%), followed by France (4,031, 7.32%) and China (2,697, 4.90%)

[PubMed] [Google Scholar] 117

Cystine-mediated uptake is critical to cellular antioxidant stress, and xCT plays a major role in maintaining low concentrations of extracellular glutamate and cystine-mediated uptake

found that inhibition of JMJD1C, a Jumonji domain-containing histone demethylase, reduces excessive accumulation of glycolytic enzymes (HK2, PGK1, LDHA) and lactate in the lungs of hypoxic mice