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The Trx system itself is a central hub of redox regulation, with its own redox status influencing numerous cellular processes beyond antioxidant defense

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Zhang F, Li ZL, Xu XM, Hu Y, Yao JH, Xu W, Jing HR, Wang S, Ning SL, Tian XF (2015) Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury

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This effect is also dose-dependent [84]

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