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This depletion compromises cellular defense mechanisms and contributes to numerous age-related pathologies including neurodegenerative diseases, cardiovascular dysfunction, metabolic disorders, and impaired immune function

Neuroinflammation in hepatic encephalopathy: mechanistic aspects

Effective treatment of arthritis often fails to cure pain

Indeed, there is emerging evidence suggesting that virus-induced type I IFN (especially IFN-/) responses affect in particular the energy and lipid metabolism both of which are essential for viral replication (Fritsch and Weichhart, 2016