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Implementing constraint-based modeling techniques, such as flux balance analysis (FBA), on network reconstructions has yielded valuable insight into gene essentiality and enzyme robustness under varying environmental conditions [11, 12]

The success of insulin therapy for diabetes, growth hormone replacement for adult-onset deficiency, and GLP-1 receptor agonists for metabolic disease all demonstrate that exogenous peptides can meaningfully restore disrupted physiology

Subsequently, an overview of the tumor microenvironment (TME) in liver cancer will be provided, accompanied by a detailed discussion on the metabolic interplay between liver cancer cells and other cell types within the TME, elucidating their biological significance

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Rapid emergence of pathogens in agro-ecosystems: Global threats to agricultural sustainability and food security