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Description

Participants exhibited a 34% reduction in Aberrant Behavior Checklist (ABC) scores, indicating reduced irritability, stereotypy, and hyperactivity

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Variable protein expression in platelets found evidence that the delE155 enzyme is present in platelets obtained from subjects that are heterozygous for the GSTO1delE155, K208 allele E173K site-directed mutagenesis of isozyme GST T1-1, the mutant shows reduced expression levels and enzyme activity with all substrates compared to the wild-type enzyme

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Expression analysis of activation markers revealed group differences between several of the identified populations

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