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E GSH in the mitochondrial matrix, the IMS and the cytosol recovers with similar kinetics To investigate the interplay of the glutathione pools of the cytosol, the IMS and the matrix, we first adapted the Grx1roGFP2 sensor for measurements in the mitochondrial compartments

Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs)

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Collectively, it seems likely that hypoxia boosts oxidant formation and mild molecular oxidative damage, which ultimately activates the antioxidant defenses

Interestingly, pre-treatment of BM showed better results than co-or post-treatment (22)