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Notably, the efficacy of the small molecule compound D34-919 has been validated in organoid models of gliomas [162]

In Arabidopsis , Al reduced the expression and activity of XTH17 and XTH31 in root cells whereas mutants of XTH17 and XTH31 exhibited improved Al tolerance by lowering hemicellulose content and retaining less Al in their cell wall (Zhu et al., 2014) Similarly, in Phaseolus vulgaris , expression of XTH genes and XET activities significantly reduced Al binding by changing cell wall porosity in root tips and enhancing Al tolerance (Zhang et al., 2016)

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