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The availability of this control probe is a key advantage of our sensor over existing probes, providing an excellent way to evaluate changes in redox homeostasis in live cells

NCOA4 deletion inhibited ferroptosis by blocking ferritinophagy and ferritin degradation, and NCOA4 over-expression increased sensitivity to ferroptosis

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The idea at the center of all these studies is that hydrogen sulfide reduces the effects of oxidative stress on cells

GSH can be converted to the oxidized form glutathione disulfide (GSSG), which is then converted back to GSH via nicotinamide adenine dinucleotide phosphate (NADPH)-dependent glutathione disulfide reductase (GSR) 134