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Drug Des Devel Ther 12 Hellewell SC, Yan EB, Agyapomaa DA, Bye N, Morganti-Kossmann MC (2010) Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses

Hereditary TH deficiency causes L-DOPAresponsive dystonia (DRD), an autosomal recessive movement disorder that can present in childhood or adolescence, with different degrees of severity, and is characterized by progressive dystonia with diurnal variation, and response to treatment with L-DOPA [34,35]