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Folic acid can lead to a decrease in DNA methyltransferase 3a (DNMT3a) expression, which downregulates the methylation level of the forkhead box P3 (FOXP3) promoter region, thereby increasing the expression of FOXP3, an important transcription factor for Treg cells that can alleviate liver inflammatory injury in ALD

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FIGURE 4 TUNEL staining was observed in both the endothelium lining the portal veins as well as scattered in the sinusoidal endothelial cells (SEC) after 1 and 5 days of frozen storage in the presence of X/Z-1000 (Figures 5A,E)

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