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4428-A PFOA EXPOSURE RESULTS IN SEX-DEPENDENT EFFECTS ON HEPATIC AND WHOLE-BODY LIPID HOMEOSTASIS THAT DIFFER BY PPARA STATUS Frederick Ekuban 1 , Greylin Nielsen 2 , Dibson Dibe Gondim 1 , Wendy Heiger-Bernays 2 , Thomas Webster 2 , Matthew Cave 1,3 and Jennifer Schlezinger 2 , (1)University of Louisville, Louisville, KY, (2)Boston University, (3)Robley Rex VAMC Background: Per- and polyfluoroalkyl substances (PFAS) are a large group of persistent chemicals that have been released pervasively in the environment leading to widespread exposure for human populations

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Studies also suggest benefits like reducing carcinogenesis, protecting retinal and brain function, improving cardiovascular health, and aiding nervous tissue development, with potential applications for neurodegenerative diseases such as Parkinsons and Alzheimers

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However, research on ferroptosis mechanisms in CHD remains in its nascent stages, with numerous crucial questions awaiting resolution