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Despite decades of research, RAs etiology remains only partially understood, and current therapeutic strategies, including biologic agents, often show variable efficacy and high failure rates across patients (67, 193)

Tang S-T, Wang C-J, Tang H-Q, Zhang Q, Wang Y

Begin with lower frequency and always patch test prior to full application

Therefore, its predictable that the combination of glutaminase inhibitors and chemotherapy may own the potential on re-sensitizing paclitaxel and cisplatin-resistant cancer cell lines to chemotherapy ( The emergence of secondary drug resistance is the main reason for the failure of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as targeted therapy for non-small cell lung cancer ( EGFR mutations in NSCLC cells significantly increase the expression of the Gln transporter(SLC1A5), which increases Gln input

Elevated levels of the protein Sir2 in resistant parasites lead to increased MDR1 expression, enhanced drug efflux, reduced ROS levels, and decreased apoptosis, contributing to higher resistance to AmB