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In endothelial cells, the ERK1/2 pathway is activated in a Ca 2+ -dependent manner 48,49 and ERK1/2 activation exacerbates renal fibrosis 50

Bowlus CL, Arriv L, Bergquist A, Deneau M, Forman L, Ilyas SI, et al

Cardiovasc Toxicol 22(9):831841

The compositions of the invention supplement the chemotherapeutic action by addressing additional processes and pathways not addressed by chemotherapeutics and on which the cancer cells of the patient could rely for energy, unchecked proliferation, and migration if such processes and pathways were not controlled or normalized