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Consider this study from Japan, where kidney dialysis patients with polyneuropathy received 5,000 g of B12 three times a week for half a year

Because activation of mTOR inhibits autophagy, which is essential for the removal of unneeded or damaged proteins and organelles, there is evidence that amino acids may contribute to cognitive decline and synaptic dysfunction at least in part via activation of mTOR (Meijer et al., 2015

Most patients tolerate these treatments very well with no additional complications

They found that in addition to slowing the progression of degeneration in the treatment group compared to controls, the peptide also improved levels of the protein aggrecan

Clinical Pharmacology for Cyanocobalamin Vitamin B 12 is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis