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Curcumin is generally considered safe by the FDA, with no major side effects observed at doses of up to 12 g/day [325]

Furthermore, similar analysis were observed in transgenic models of PD under different promoters, with reports of motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] -syn mice and (Thy-1)-h[A53T] -syn mice (Ekmark-Lewen et al., 2018) (Table 1)

Pretreatment with PGG (100 or 200 mg/kg, orally) for 8 days prior to the administration of indomethacin furnished significant reductions in gastric mucosal lesions as well as a significant increase in mucus concentration

In the case of glutathione, the liposomes keep it in its reduced, or biologically active state

The drug is entrapped within the solid lipid matrix, leading to a slower release through diffusion as the NP gradually erodes or the drug partitions out of the lipid matrix