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Stromal cells depart the cell cycle to differentiate into decidualized cells, a process mediated by transcription factors including C/EBPs, FOXO1, CREB and STAT5 ( Senescence of endometrial fibroblasts has been associated with poor reproductive outcomes

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While low ALP activity may indicate a poor prognosis in advanced or metastatic CRC, is similar to that in breast cancer, but opposite to that in other cancers, indicating that the mechanism of ALP action in cancer is a double-edged sword