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Nonetheless, long-term opioid therapy has a role in the treatment of some patients when used selectively, carefully and combined with an ongoing assessment of risks and benefits

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The contribution of circulating versus locally produced IGF-1 in kidney development was investigated using a hepatic specific JAK2 knockout in mice [28]

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Similarly, ablation of IGF-IR in cultured osteoclast precursors reduces the number and size of osteoclasts and their expression of RANK, c-fms, and NFATc1 (unpublished data)

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