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doi:10.1002/jbmr.4709 Douaud G, Refsum H, de Jager CA, et al

When to call a professional Contact your doctor for a physical examination if you experience unexplained fatigue, palpitations, shortness of breath, sore tongue, or any other symptoms of vitamin B 12 deficiency

And there are weight loss and mental health benefits, too

This ensures an accurate assessment of B12 status, the identification of any underlying conditions contributing to deficiency, and the development of an appropriate treatment plan

Using the calculator, entering a target dose of 2,000mcg shows that the required draw is 0.2mL, equal to 20 units on a U-100 syringe