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In addition, cisplatin cytotoxicity is reduced in c-Abl defective cells [33]

Free Radic Biol Med 46(1):6269

To further understand the role played by the RRM2 gene in the whole biological behavior of tumors, we performed a pan-cancer analysis by the combination of TCGA and GTEx data, which showed that RRM2 was generally highly expressed in tumors of epithelial origin, such as THCA, esophageal carcinoma, and breast carcinoma, suggesting that its pro-carcinogenic mechanism is conserved by the cancer species