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1) Impaired histamine breakdown: There are two ways your body breaks down and clears histamine: the DAO enzyme or the HMNT enzyme.[ref] Diamine oxidase (DAO) enzyme: breaking down and inactivating histamine in the gut Diamine oxidase is encoded by the AOC1 gene

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This can lead to the development of specific antibodies that neutralize the drug or cause allergic reactions, potentially resulting in serious complications for patients

Figure 7 Measurement of the cytosolic E GSH in severely glutathione-deficient rml1 mutants GSH Conventional roGFP1 and roGFP2 are highly reduced when expressed in the cytosol of non-stressed cells (Meyer et al., E GSH