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Description

M1 macrophages exhibit dysregulated iron metabolism, with increased expression of hepcidin (Hamp) and ferritin heavy/light chains (FTH/FTL), and reduced expression of ferroportin (FPN) and IRP1/2 (88)

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H.KeimJ.et al (2021)

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However, the human genome may not have adapted to this "recent switch" to higher IIS driven by Western diet

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2.1.1 Glutathione peroxidase 4 Antioxidant defense systems, such as GPX4, play a critical role in protecting cells from ferroptosis (146)

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