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By rupturing phagocytic vesicles, LLO makes it possible for bacteria to enter the cytoplasm

At 10 dpl, we identified by immunofluorescence newly formed OLs (YFP + cells) being either Bcas1, a marker of immature/pre-myelinating OLs 85 , or GST, a marker restricted to myelinating OLs 78

This is supported by reductions in neuroinflammatory mediators, including TNF-, IL-1, and iNOS, alongside the downregulation of TLR4 transcriptional regulators, such as p-c-Jun and PU.1 [171]

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