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Caffeine shows significant chronic psychoactive metabolite accumulation with daily use [34], while paraxanthine and 1-MX have mostly-inactive metabolites that are rapidly excreted [35]

Finally, we highlight the challenges that face the therapeutic targeting of the MAT2A/PRMT5 axis, the need for additional predictive biomarkers other than MTAP status, and how these biomarkers could predict rational combination therapies

[DOI] [PMC free article] [PubMed] [Google Scholar] Szultka M, Buszewska-Forajta M, Kaliszan R, Buszewski B

Cell (2012) 149:126983

A randomized, double-blind, placebo-controlled trial in 60 healthy older adults (mean age, 68.5 years) investigated whether acute (80 mg) or chronic (80 mg/day for 4 weeks) oral intake of curcumin could improve their ability to cope with the mental stress and change in mood usually associated with undergoing a battery of cognitive tests (97)