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During the inflammtory response, cells release various inflammtory mediators such as prostaglandins, leukotrienes, etc

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The Khavinson primate studies are most relevant here: Epitalon increased nighttime melatonin in old monkeys while having no effect on young ones

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In addition, TLR2 inhibition has been reported to reduce SLE-associated symptoms further indicating that hyperresponsiveness to gut bacteria is likely to contribute to disease pathogenesis (Pawar et al