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We also generated hybrid organoids mixing mutated and control progenitors to assess the role of each cell type in determining the disease phenotype

Discussion The present study showed that 3MST produces persulfurated species such as Cys-SSH and GSSH together with H 2 S 2 and H 2 S 3 as signaling molecules, and increases the levels of persulfurated proteins in a similar manner (Figs 1, 37, and Supplementary Figs S4 and S5) 14, 26, 40

also demonstrated that VNS significantly increased synaptic plasticity in cortico-brainstem circuits that regulate upper limb movements and enlarged cortical areas (Morrison et al., 2020, 2021)