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10.1016/j.ymthe.2017.11.015 2 AmadoD

*** In Memoriam Nov

Removal by natural or artificial mutation of this arginine residue completely abolishes glutamine feedback inhibition in these GS homologue similar to the Bacillus subtilis GS homologue

Unbalanced chain accumulation dominates the clinical phenotype

note that MMA is not universally available on the NHS and can also be raised in renal impairment Homocysteine raised in both B12 and folate deficiency