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Main Phase (Baseline to Week 26): Study 1 (NCT 00123253) This study randomized 412 HIV-infected patients with lipodystrophy and excess abdominal fat to receive either a 2 mg dose of EGRIFTA (1 mg/vial formulation) (N=273) or placebo (N=137)

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Interestingly, AMD3100 reversed this benefit, producing a 55% increase in nitrotyrosine compared to DOX + GHRP-6, further implicating CXCR4 in regulating oxidative stress

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