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Insulin-like growth factor long arginine 3 (IGF-1 LR3), is a widely used synthetic analog of IGF-1 with an arginine replacing glutamic acid at position 3 (arginine 3, R3), and an additional 13 amino acids at its N-terminus (long, L)

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This review deliberately excluded studies examining synthetic mitragynine analogs or chemically modified derivatives to maintain a mechanistic focus on naturally occurring kratom alkaloids as they occur in traditional and contemporary preparations [10]

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