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Specifically, the ROS scavenger butylated hydroxyanisole delayed TNF-induced necroptosis but had no effect on necroptosis induced by direct RIPK3 oligomerization, suggesting that ROS may facilitate upstream signaling events rather than serve as an obligate execution mechanism 80

S2CID 205563521

Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)