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Zanubrutinib was compared to ibrutinib in patients with relapsed or refractory CLL in the Phase 3 ALPINE study.52,53 Zanubrutinib was superior to ibrutinib with 2-year PFS rates of 78.4 % versus 65.9 % (p-value = 0.002)

Science 347(6229):1255957 Jacques A, Laurent M, Ribiere-Chabert M, Saussac M, Bougeard S, Hendrikx P, Chauzat MP (2016) Statistical analysis on the EPILOBEE dataset: explanatory variables related to honeybee colony mortality in EU during a 2 year survey

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It is strongly advisable to bring your questions and concerns to a licensed medical practitioner who will be able to provide clear guidance on the effectiveness of hormone replacement therapy in your individual circumstances