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For example, in a murine model exposed to chronic hypoxia (10% O 2 ), the conditional deletion of HIF-2 in vascular cells (Wt1 lineage) resulted in cardiomegaly, ventricular hypertrophy, dilation, and systolic dysfunction, indicating that vascular signaling mediated by HIF-2 contributes to preserving cardiac homeostasis under chronic hypoxia [93]

Effects of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig

The dithiolethione compound OPZ reached Phase III clinical trials for schistosomiasis treatment [42] before it was withdrawn because of adverse side affects [56]

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The details on the GSM model comparison for all the generated models is available in Supplementary Data 1