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However, treatment with LUT-EX@MN effectively reversed this increase, resulting in the lowest MYOC gene expression, which was a 1.16-fold increase compared to the levels observed in the negative control group

APE/Ref-1 is a multifunctional protein in the DNA base repair pathway that is responsible for repairing apurinic/apyrimidinic sites in DNA after oxidation (Fritz et al., 2003)