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Colocalization in images was analysed using Pearsons colocalization coefficient (Zen Imaging Software, Carl Zeiss AG) as the data was tested to be normal distributed and without outliers

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Furthermore, heterogeneity in tumour stage (or indeed, location), patient populations and treatment dose and duration is likely to confound reported response data, particularly given the links between changes in oxidative metabolism and metastatic spread 84,85,86,87

Its glucose-lowering action is particularly useful for patients with insulin resistance or pre-diabetes alongside excess weight, because improving insulin sensitivity changes how the body stores and mobilizes fat

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