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In the DOX-induced heart failure model, the GPX4 expression is downregulated, triggering lipid peroxidation of the DOX-Fe 2+ complex and inducing mitochondria-dependent ferroptosis ( Tyrosine kinase inhibitors (TKIs) are also a class of anticancer agents for various cancers ( 3.5 Heart failure Heart failure is the terminal stage of various cardiovascular diseases ( Of note, ferritin heavy chain (FTH), a significant component of ferritin, is down-regulated in transverse aortic constriction mice ( 3.6 Hypertension Hypertension is a common comorbidity in HFpEF patients with high angiotensin II (Ang II) levels and myocardial fibrosis ( 3.7 Other cardiovascular disease Iron overload in diabetic patients increases the insulin resistance risk and aggravates cardiovascular complications through the Fenton reaction ( Patients with severe sepsis often present with cardiac injury and dysfunction

The first identified enzyme was cation transport regulator protein 1 (CHAC1), which was originally reported as a proapoptotic component [105]

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doi: 10.1016/1074-5521(95)90076-4

Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness