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Lymphoma 63 (3), 722728

Skin T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol

This is primarily mediated by the anti-apoptotic properties of sphingosine-1-phosphate (S1P) in HDL, which prevents the opening of mitochondrial permeability transition pores by activating the SAFE (Survivor Activating Factor Enhancement) and RISK (Reperfusion Injury Salvage Kinase) pathways

But they are not backed by the randomized controlled trials that FDA-approved products have undergone

All current evidence is animal or in vitro no completed human trials exist for Dihexa itself