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Bremmer et al PLoS ONE 2011 Archived 2014-03-26 at the Wayback Machine External links [edit] Methemoglobin at the U.S

The regulation of system X c /GSH/GPX4 axis in ferroptosis As the main antioxidant system against ferroptosis, the role of System X c /GSH/GPX4 axis is crucial in the treatment of various types of drug-resistant solid tumors, so an in-depth understanding of the regulatory mechanism of each node on this axis is of great significance for developing effective strategies for System X c /GSH/GPX4 axis targeted treatment of drug-resistant solid tumors (Figure 1)